Gank squishy mids at level 6, Vendetta plus Impale and Mana Burn kills most laners outright.

Spam Mana Burn on intelligence cores, the damage scales with their mana pool and cripples them.

Pop Spiked Carapace right after you initiate, it reflects their retaliation and stuns attackers.

Use Vendetta to scout enemy movements and set up ganks before your team commits.

Max Impale early for the long stun, then gank sidelane carries who have low health and armor.

Roam when your ultimate is up and farm when it is not, Nyx wins through constant map pressure.