Smoke Screen silences and disables items, so drop it on the enemy core before they BKB or Blink out.

Tricks of the Trade makes you invulnerable and hits from every angle, use it to dodge nukes and finish kills.

Blink Strike behind targets for backstab bonus, and keep a charge in reserve for escape.

Place Smoke Screen on the escape path so enemies must walk through it to retreat.

Rush Diffusal Blade for the slow and mana burn, then hunt isolated supports.

Cancel channeled spells like teleports and ultimates with Smoke Screen.